Total Synthesis of Marine Cyclic Enol-Phosphotriester Salinipostin Compounds     

ZHAO Mingliang  WEI Xianfeng  LIU Xuemeng  DONG Xueyang  YU Rilei  WAN Shengbiao  JIANG Tao 《中国海洋大学学报(英文版)》2018,(3)

Due to their structural diversity and variety of biological activities, marine natural products have been the subject of extensive study. These compounds, especially phospholipid polycyclic aromatic hydrocarbons, have a wide range of pharmacological applications, including embedded DNA and central nervous system, anti-tumor, anti-virus, anti-parasite, anti-bacterial, and antithrombotic effects. Unfortunately, the insufficient drug sources have limited the development of these compounds. In this study, we isolated salinpostin compounds from a fermentation solution of marine-derived Salinospora sp., which has a common bicyclic enol-phosphotriester core framework, as well as potent and selective antimalarial activities against P. falciparum with EC_(50)=50 nmolL~(-1). The chemical synthesis of these compounds in greater quantities is necessary for their use in bioactivity studies. Thus we explored a short route with high yields and mild reaction conditions, which can generate combinatorial libraries for drug discovery and lead optimization. We developed a new total synthesis method for six cyclic enol-phosphotriester salinipotin compounds and their diastereomers. For the total synthesis of cyclipostin P, we prepared cyclic enol-phosphotriester salinipostin compounds in 10 steps from a readily accessible starting material, 1,3-dihydroxyacetone, and obtained an overall yield of 1.29%. We fully characterized these compounds by proton nuclear magnetic resonance(~1H-NMR), carbon-13 NMR(~(13)C-NMR), and high-resolution mass spectrometry(HRMS) analyses, and found they coincide absolutely with the same compounds reported previously.  相似文献   

A Preliminary Genetic Linkage Map of Sinonovacula constricta(Lamarck, 1818) Based on Microsatellites Derived from RAD Sequencing     

WU Xueping  FENG Yanwei  JIANG Hailin  LIU Xiangquan  PAN Ying 《中国海洋大学学报(英文版)》2018,(4)

Sinonovacula constricta is one of the important economic aquaculture species in China. In this study, we constructed genetic linkage maps of S. constricta based on 300 microsatellite markers derived from RAD-seq using an F1 full-sib family. The female map contained 204 microsatellites assigned to 22 linkage groups, which covered 1529.5 cM with an average interval of 10.3 cM. The male consisted of 187 microsatellites in 19 linkage groups corresponding to the haploid chromosome number(n(28)19), which spanned 1429.3 cM with an average interval of 8.7 cM. The genome coverage was approximately 83.5% and 81.4%, respectively. An integrated map was constructed according to the common markers in parental linkage groups, which had a total length of 1683.8 cM with an average interval of 7.3 cM. The genome coverage of the integrated map was approximately 86.3%. The genetic linkage map would form the foundation for further studies on the quantitative trait loci(QTL), as well as accelerating the breeding process of this species.  相似文献   

世越号起吊姿态敏感性分析与方案选择     

姚宗  蒋岩  王伟平  陈世海 《海洋工程》2018,36(2):135-142

韩国世越号打捞是世界上首次利用托底钢梁原状态整体起吊难船出水的工程。客滚难船装载的货物容易在沉没后发生移位,上层建筑长时间沉没海底后发生泥沙淤积导致难以准确估计整船的重量重心及浮力浮心的位置。利用水池模型试验和数值计算两种方法分别对大型浮吊船单臂架打捞法和双驳船抬吊打捞法进行了难船姿态受重心位置偏移的敏感性分析。水池模型试验中发现,用大型浮吊船单臂架打捞法,世越号的姿态受其重心位置偏移非常敏感,容易发生侧翻;而用双驳船抬吊打捞法,世越号的姿态受其重心位置的影响非常有限,难船和抬浮驳船都可以保持一个较好的姿态。对比水池模型试验的结果,由于难以计及托底钢梁的翘动和滑动现象,数值计算中得到的难船起吊姿态值偏小。双驳船抬吊打捞法被选为打捞世越号的施工方案,其对难船重心位置偏移不敏感的特性得到了现场实证。这个特点为世越号的成功打捞出水起到了关键作用。  相似文献   

Application of computational fluid dynamics simulation for submarine oil spill     

YANG Zhenglong  YU Jianxing  LI Zhigan  CHEN Haicheng  JIANG Meirong  CHEN Xi 《海洋学报(英文版)》2018,37(11):104-115

  相似文献   

风和径流量对长江口缺氧影响的数值模拟   总被引：1，自引：1，他引：0  

郑静静  刘桂梅  高姗  李云  李志杰 《海洋学报》2018,40(9):1-17

受自然和人类活动的影响，海洋缺氧现象日益严重，威胁着海洋生态环境，海洋缺氧问题已经引起了人们的广泛关注。本文应用区域海洋模式并耦合生态模式，对东海的生态系统进行了数值模拟和分析研究。与观测数据比较显示，该模型能较好地模拟长江口外生态变量的分布趋势。另外本文通过设置不同敏感性实验，探讨风和径流量对长江口底层缺氧现象的影响，结果分析表明，风和径流量对长江口外缺氧区的形成有显著的影响。径流量变化虽然对长江口外缺氧区的季节变化影响并不显著，但是对缺氧区域面积却存在显著的影响。径流量增加，水体层化增强，表层叶绿素浓度增加，最终导致缺氧区域范围扩展；径流量减小，水体层化减弱，表层叶绿素浓度减小，缺氧区域范围缩小。风向和风速的改变不仅影响长江口外缺氧区的季节变化，还影响缺氧区域面积。  相似文献   

Radio variability of the blazar S5 0716+714: a ∼6.1 year quasi-periodicity     

Xiao-Pan Li  Yu-Hui Luo  Hai-Yan Yang  Cheng Yang  Yan Cai  Hai-Tao Yang  Li Zhou  Yu-Qiong Shan 《Astrophysics and Space Science》2018,363(8):169

We report a ～6.1 yr quasi-periodicity for the blazar S5 0716+714 using the radio light curves at 4.8, 8 and 14.5 GHz observed by the University of Michigan Radio Astronomical Observatory (UMRAO) from 1981 to 2012, by means of the Jurkevich, discrete correlation function (DCF) and power spectral analysis techniques. There are a general correlation among light curves at different frequencies and a time lag of \(170\pm 10\) days between 4.8 and 14.5 GHz light curves can be confirmed. We also estimate the orbit parameters assuming a binary black hole system, and the magnetic field strength under the jet comoving frame.  相似文献   

两种造礁石珊瑚对海水酸化和溶解有机碳加富的响应*     

郭亚娟  周伟华  袁翔城  廖健祖  江雷  黄晖 《热带海洋学报》2018,37(1):57-63

文章选择鹿回头近岸海域常见的板叶角蜂巢珊瑚(Favites complanata)和十字牡丹珊瑚(Pavona decussata)为研究对象, 采用室内连续培养的方法, 探究两种不同造礁石珊瑚对酸化和溶解有机碳(DOC)加富的响应。结果表明: 酸化(pH 7.6)并不会影响两种珊瑚的钙化速率和生长速率; 但DOC加富(524.03±78.42μmol•L^-1)使两种珊瑚的钙化速率分别降低67%和47%、生长速率降低59%和40%。当二者共同作用时, 两种珊瑚的钙化速率降低30%和11%、生长速率降低46%和59%, 大多没有DOC单独作用时强烈, 表现出一定的拮抗作用。两种珊瑚共生虫黄藻叶绿素荧光指数(F_v/F_m)均升高后降低, 板叶角蜂巢珊瑚F_v/F_m最先降低。实验表明, 这两种珊瑚虽然对海洋酸化的敏感度不高, 但是对有机物加富有不同的响应, 板叶角蜂巢珊瑚更为敏感, 可能导致这两种珊瑚在未来环境变化中有不同命运。  相似文献   

基于经验模态分解和小波分解估算海气通量涡相关计算中的截断时间尺度     

姜浩  赵中阔  樊伟  宋金宝 《海洋与湖沼》2018,49(6):1138-1150

基于时长38天的海表风场实测数据,应用经验模态分解(EmpiricalModeDecomposition,EMD)和小波分解(Wavelet Decomposition, WD)这两种数据处理方法首先对涡相关法中的截断时间尺度(CutoffTimescale,CTS)进行估算,结果显示:基于EMD与WD方法估算出的CTS一般都在40秒左右(EMD的结果略小),远远小于传统涡相关法中CTS的取值(固定为10分钟),且EMD和WD的使用使得每一段数据都能够根据自身的湍流特点而获得合适的CTS; EMD方法和WD方法有效的去除了计算结果中的非湍部分,且对通量传输方向的刻画也更加合理,极大提高了通量的计算精度,所得通量与传统方法计算的通量偏差平均值高达45%;研究还对EMD和WD的优缺点进行了对比分析,结果表明EMD相比于WD有更高的自主性,而WD对信号的分离程度则更高。  相似文献   

青州市表层土壤元素地球化学组合特征研究   总被引：1，自引：0，他引：1       下载免费PDF全文

姜冰  刘阳  颜丙鹏 《山东国土资源》2018,34(9)

聚类分析和因子分析可以获得土壤元素地球化学组合特征及其差异性。对青州市表层土壤样品数据进行分析研究,通过聚类分析,绘制表层土壤元素聚类谱系图,将23种元素或指标分为5个元素组合簇群及2个单元素簇,研究各元素间的组合特征,探讨其相关性、聚集性及其指示意义;通过因子分析,找出有代表性的因子,用其代表变量,绘制典型因子得分等值线图,并从中分析不同元素组合的区域分布基于何种因素,用11个代表性因子的分布特征就基本可以代表青州市表层土壤23项原始变量的分布特征,并对F1,F2,F3主因子进行了地质解释。聚类分析与因子分析相结合,利于表层土壤中元素的共生组合特征及其差异性研究,利于对研究区表层土壤异常进行归纳总结。  相似文献   

绝对重力仪的自由落体凸轮驱动器设计与仿真     

张黎  邹彤  蒋冰莉 《大地测量与地球动力学》2018,38(1):102-105

提出一种适合绝对重力仪的凸轮驱动器设计方法，研究了具体运动过程，基于自由落体运动得到凸轮驱动器的运动曲线，并采用SolidWorks进行仿真验证。结果表明，该设计方法可以解决绝对重力仪的自由落体凸轮驱动器设计实现问题。  相似文献